Two MSCs lead cell-based therapy

豊田さんの論文が公開されました

以下のサイト

http://rdcu.be/E3LT

Cartilage generated from sees2

cartilage generated from SEES2

http://opentein.hgc.jp/manager/viewSlide.php?mode=1&sl_name=akihiroumezawa:2059

Route of Administration (ROA) and Devices

「安全性」と「試験の質」

Mechanism/Mode of Action (MOA) 

versus 

どのような形態で投与するか。

日本臨床薬理学会　S33-3 抄録より抜粋

Regenerative Therapy インパクトファクター取得!!!!!!!!

https://www.journals.elsevier.com/regenerative-therapy/news/regenerative-therapy-now-convered-in-scie

やっとインパクトファクターを取得。おめでとうございます!!　心よりお祝い申し上げます!!

Our Melanocyte product from NCCHD

https://drive.google.com/file/d/19YGRzOD3UZa9r6XFQm7z0g2mf69-VAQB/view

Melanocytes, branched dendriticcells of neuro-ectodermal origin are specialized pigment producing cellslocated mostly at the base of the epidermis of vertebrate animal skin. Thepigment, melanin is synthesized from the amino acid tyrosine by tyrosinaseenzyme and stored in the special organelle called melanosomes as melaningranules. The melanin granules are transferred to surrounding keratinocytesthrough the melanocyte dendritic extremities and are responsible for skin,hair, and eye color in vertebrate organisms. Melanin pigment provides an effective protection to skin againstultraviolet radiation by absorbing the UV radiation and UV inducedintracellular free radicals. In addition to the UVprotection, melanocytes also play an important role in hearing system, immunesystem and several disease conditions such as vitiligo, melanoma, melisma, dysplastic naevus, lentigo, BK-molesyndrome, albinism etc.

 

Established melanocyte cellline is a vital research tool for variety of applications including

   Researchon Melanogenesis

   2D& 3D skin models

   Bio-printingof skin

   Preclinicaland clinical research on Cell therapy

   Regenerativemedicine (e. g. Vitiligo)

   Basicresearch on the biology of skin

   Malignantmelanoma and other skin diseases/disorders

   Effectof Ultraviolet Radiation

   CosmeticsResearch—efficacy and toxicology

 

 

Our Melanocytes are derived from the human embryonicstem cells (hESC SEES3) using an in-house established protocol and speciallyformulated cell culture medium. The branched elaborated structures ofmelanocytes are clearly visible in the monolayer culture with or without matrixsupport. Melanocytes can grow and multiply in the Melanocyte Growth Medium (M254CF,Gibco Cat. no. M-254CF-500) supplemented with calcium plus Human Melanocyte Growth Supplement(HMGS, Gibco, HMGS, cat. # S-002-5).