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Cardiovascular Disease
Hypertension
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A substantial body of epidemiological and experimental research is linking magnesium deficiency and cardiovascular diseases such as hypertension and atherosclerosis . Hypertension is a major risk factor for heart disease and stroke. Magnesium is involved in blood pressure regulation. Every modification of the endogenous magnesium status leads to changes in vascular tonus and, as a consequence, changes in arterial blood pressure . 

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Magnesium deficiency increases angiotensin II-mediated aldosterone synthesis and the production of thromboxane and vasoconstrictor prostaglandins (see Figure 3) .Furthermore, alterations in the metabolism of calcium and magnesium have been implicated in the pathogenesis of primary hypertension. 

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Calcium influx across the external cellular membrane in smooth muscle cells and cardiomyocytes plays a crucial role in the control of cellular excitation contraction and impulse propagation. Intracellular calcium and magnesium concentrations are controlled by reversible binding to specific calcium-binding proteins. ¡ÊÃæÎ¬¡Ë

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The calcium and magnesium flux across the external membrane is regulated by a calcium pump (calcium-magnesium-ATPase), calcium channels, and binding to the membrane.  In cell membranes and in lymphocytes of hypertensive patients, our group showed significant increase of calcium, decrease of magnesium and an increased calcium/magnesium ratio (Ca2+/Mg2+ >2) . In addition, it could be shown experimentally that a lack of magnesium increases the risk for lipid peroxidation and the development of dyslipoproteinemia.

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In a meta-analysis of randomized trials, the effect of magnesium supplementation on blood pressure was tested. 

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 In borderline hypertension, decreased intracellular magnesium concentrations have recently been described. In patients with mild uncomplicated hypertension, respectively borderline hypertension, magnesium therapy can normalize blood pressure values . Magnesium supplementation may also have a positive effect on resting and recovery systolic blood pressure with aerobic and resistance exercise . 

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Magnesium supplementation can help to control blood pressure and reduce the cardiovascular risk factors (e.g., atherosclerosis) associated with hypertension, especially in hypertensive individuals who are depleted of magnesium due to chronic diuretic use, inadequate intake, or both .

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Coronary Heart Disease, Myocardial Infarction and Stroke
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Magnesium is a natural calcium antagonist and modulates vasomotor tone, blood pressure, and peripheral blood flow. Its actions as an antihypertensive, antidysrhythmic, anti-inflammatory and anticoagulant agent can be of benefit in the prevention and treatment of cardiovascular diseases. 

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Recent experimental studies with Wistar rats reveal that short magnesium deficiency is associated with a downregulation of telomerase in left ventricular, right ventricular, atrial and aortic muscle cells. 

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Furthermore a deficiency of magnesium resulted in these animal models in a 7–10 fold increased formation of 8-OH-dG in the cardiac and aortic muscle cells, and furthermore the magnesium deficiency is linked to an increased upregulation on neutral-sphingomyelinase (N-SMAse) and p53 in the cardiac and aortic muscle tissues . 

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Epidemiological studies have reported that serum and dietary magnesium are associated inversely with risk factors for coronary heart disease such as hypertension, type 2 diabetes mellitus, and the metabolic syndrome. Additional evidence from ecologic, clinical, and autopsy studies has shown higher magnesium to be potentially protective against sudden cardiac death. 

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