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7.2. Cardiovascular Disease
7.2.1. Hypertension
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£·¡¥£²¡¥£±¡£¹â·ì°µ A substantial body of epidemiological and experimental research is linking magnesium deficiency and cardiovascular diseases such as hypertension and atherosclerosis .Hypertension is a major risk factor for heart disease and stroke. Magnesium is involved in blood pressure regulation. Every modification of the endogenous magnesium status leads to changes in vascular tonus and, as a consequence, changes in arterial blood pressure
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Furthermore, alterations in the metabolism of calcium and magnesium have been implicated in the pathogenesis of primary hypertension. Calcium influx across the external cellular membrane in smooth muscle cells and cardiomyocytes plays a crucial role in the control of cellular excitation contraction and impulse propagation. Intracellular calcium and magnesium concentrations are controlled by reversible binding to specific calcium-binding proteins.
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The calcium and magnesium flux across the external membrane is regulated by a calcium pump (calcium-magnesium-ATPase), calcium channels, and binding to the membrane. In cell membranes and in lymphocytes of hypertensive patients, our group showed significant increase of calcium, decrease of magnesium and an increased calcium/magnesium ratio (Ca2+/Mg2+ >2) . ³°Ëì¤ò²£Àڤ륫¥ë¥·¥¦¥à¤ª¤è¤Ó¥Þ¥°¥Í¥·¥¦¥à¤Îή¤ì¤Ï¡¢¥«¥ë¥·¥¦¥à¥Ý¥ó¥×¡Ê¥«¥ë¥·¥¦¥à - ¥Þ¥°¥Í¥·¥¦¥à - £Á£Ô£Ð¥¢¡¼¥¼¡Ë¡¢¥«¥ë¥·¥¦¥à¥Á¥ã¥Í¥ë¡¢¤ª¤è¤ÓËì¤Ø¤Î·ë¹ç¤Ë¤è¤Ã¤ÆÄ´Àᤵ¤ì¤Þ¤¹¡£
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Magnesium is a natural calcium antagonist and modulates vasomotor tone, blood pressure, and peripheral blood flow. Its actions as an antihypertensive, antidysrhythmic, anti-inflammatory and anticoagulant agent can be of benefit in the prevention and treatment of cardiovascular diseases. Recent experimental studies with Wistar rats reveal that short magnesium deficiency is associated with a downregulation of telomerase in left ventricular, right ventricular, atrial and aortic muscle cells.Furthermore a deficiency of magnesium resulted in these animal models in a 7–10 fold increased formation of 8-OH-dG in the cardiac and aortic muscle cells, and furthermore the magnesium deficiency is linked to an increased upregulation on neutral-sphingomyelinase
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Epidemiological studies have reported that serum and dietary magnesium are associated inversely with risk factors for coronary heart disease such as hypertension, type 2 diabetes mellitus, and the metabolic syndrome. Additional evidence from ecologic, clinical, and autopsy studies has shown higher magnesium to be potentially protective against sudden cardiac death. ±Ö³ØÅª¸¦µæ¤Ï¡¢·ìÀ¶ÃæµÚ¤Ó¿©»ö¤Ë¤è¤ë¥Þ¥°¥Í¥·¥¦¥à¤¬¡¢¹â·ì°µ¡¢2·¿ÅüǢɡ¢¤ª¤è¤Ó¥á¥¿¥Ü¥ê¥Ã¥¯¥·¥ó¥É¥í¡¼¥à¤Ê¤É¤Î´§¾õư̮À¿´Â¡ÉÂ¤Î´í¸±°ø»Ò¤ÈµÕ¤Î´Ø·¸¤Ë¤¢¤ë¤³¤È¤òÊó¹ð¤·¤Æ¤¤¤Þ¤¹¡£
À¸ÂÖ³ØÅª¡¢Î×¾²Åª¡¢¤ª¤è¤Ó˶¸¡¤Î¸¦µæ¤«¤é¤ÎÄɲäξڵò¤Ï¡¢¤è¤ê¹â¤¤¥Þ¥°¥Í¥·¥¦¥à¤¬¿´Â¡ÆÍÁ³»à¤ËÂФ·¤ÆÀøºßŪ¤ËÊݸîŪ¤Ç¤¢¤ë¤³¤È¤ò¼¨¤·¤Þ¤·¤¿¡£ The Atherosclerosis Risk in Communities (ARIC) Study assessed risk factors and levels of serum magnesium in a cohort of 7887 women and 6345 men aged 45–64 years. After an average of 12 years of follow-up, individuals in the highest quartile of the normal physiologic range of serum magnesium (≥0.88 mmol/L) had an almost 40% reduced risk of sudden cardiac death compared with individuals in the lowest quartile (≤0.75 mmol/L) (HR: 0.62, 95% CI: 0.42–0.93) . Ãϰè¤Ë¤ª¤±¤ë¥¢¥Æ¥í¡¼¥àÀư̮¹Å²½¾É¥ê¥¹¥¯¡ÊARIC¡Ë»î¸³¤Ç¤Ï¡¢45〜64ºÐ¤Î½÷À7887¿Í¤ÈÃËÀ6345¿Í¤Î¥³¥Û¡¼¥È¡Ê½¸ÃĤδѻ¡Åª¸¦µæ¡Ë¤Ë±÷¤±¤ë´í¸±°ø»Ò¤È·ìÀ¶¥Þ¥°¥Í¥·¥¦¥àÇ»ÅÙ¤¬É¾²Á¤µ¤ì¤Þ¤·¤¿¡£
Ê¿¶Ñ12ǯ´Ö¤ÎÄÉÀ×Ä´ºº¤Î¸å¡¢Àµ¾ï¤ÊÀ¸ÍýŪÈϰϤηìÀ¶¥Þ¥°¥Í¥·¥¦¥à¤ÎºÇ¹â»Íʬ°Ì¿ô¡Ê¡æ0.88mmol / L¡Ë¡ÊÃ𣷡ˤθĿͤϡ¢ºÇÄã»Íʬ°Ì¿ô¤Î¸Ä¿Í¤ÈÈæ³Ó¤·¤Æ¡¢¿´Â¡ÆÍÁ³»à¤Î¥ê¥¹¥¯¤¬¤Û¤Ü40¡ó¸º¾¯¤·¤Þ¤·¤¿¡£
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¥Ç¡¼¥¿¤òÂ礤µ¤Î½ç¤Ëʤ٤¿¤È¤¤ËÁ´ÂΤÎÃæ±û¤Ë°ÌÃÖ¤¹¤ëÃͤ¬Ãæ±ûÃ͡ʥ᥸¥¢¥ó¡Ë¡£Æ±¤¸¤¯¡¢¥Ç¡¼¥¿¤òÂ礤µ¤Î½ç¤Ëʤ٤¿¤È¤¤Ë²¼¤«¤é25¡ó¡¦50%¡¦75%¤Ë°ÌÃÖ¤¹¤ëÃͤΤ³¤È¤òÂè1»Íʬ°Ì¿ô¡¦Âè2»Íʬ°Ì¿ô¡¦Âè3»Íʬ°Ì¿ô¤È¸À¤¦¡£Ã±¤Ë»Íʬ°Ì¿ô¤È¤¤¤Ã¤¿¤Ð¤¢¤¤¡¢Âè1¡¦Âè3»Íʬ°Ì¿ô¤òɽ¤¹¡£Âè2»Íʬ°Ì¿ô¡Ê£µ£°¡ó¡Ë¤ÏÃæ±ûÃÍ¡£ Another prospective study examined 88,375 women to determine whether serum magnesium levels measured early in the study and magnesium intakes from food and supplements assessed every 2–4 years were associated with sudden cardiac death over 26 years of follow-up. Women in the highest compared with the lowest quartile of daily ingested magnesium (<261 mg/day vs. >345 mg/day) and plasma magnesium concentrations (<0.78 mmol/L vs. >0.86 mmol/L) had a 37% (relative risk: 0.63; 95% CI: 0.44, 0.91) and 77% (relative risk: 0.23; 95% CI: 0.09, 0.60) lower risk of sudden cardiac death, respectively . Ê̤ÎÁ°¸þ¤¸¦µæ¤Ç¤Ï¡¢88,375¿Í¤Î½÷À¤òÂоݤˡ¢¸¦µæ¤Î½é´ü¤Ë¬Äꤵ¤ì¤¿·ìÀ¶¥Þ¥°¥Í¥·¥¦¥à¥ì¥Ù¥ë¡¢¤ª¤è¤Ó2〜4ǯ¤´¤È¤Ëɾ²Á¤µ¤ì¤¿¿©Éʤª¤è¤Ó¥µ¥×¥ê¥á¥ó¥È¤«¤é¤Î¥Þ¥°¥Í¥·¥¦¥àÀݼ褬26ǯ´Ö¤ÎÄÉÀ×Ä´ºº¤ÇÆÍÁ³¤Î¿´Â¡»à¤È´ØÏ¢¤·¤Æ¤¤¤ë¤«¤É¤¦¤«¤òÄ´¤Ù¤Þ¤·¤¿¡£
°ìÆüÀݼè¥Þ¥°¥Í¥·¥¦¥à¤ÎºÇÄã»Íʬ°Ì¿ô¡Ê<261 mg /ÆüÂÐ> 345 mg /Æü¡ËµÚ¤Ó·ìÞù¥Þ¥°¥Í¥·¥¦¥àÇ»ÅÙ¡Ê<0.78 mmol / LÂÐ> 0.86 mmol / L¡Ë¤ÈÈæ³Ó¤·¡¢ºÇ¤â¹â¤¤½÷À¤Ï37¡ó¡Ê ÁêÂХꥹ¥¯¡§0.63¡¢95¡óCI¡§0.44¡¢0.91¡ËµÚ¤Ó77¡ó¡ÊÁêÂХꥹ¥¯¡§0.23¡¢95¡óCI¡§0.09¡¢0.60¡Ë¤â¿´Â¡ÆÍÁ³»à¤Î¥ê¥¹¥¯¤¬¤½¤ì¤¾¤ìÄ㤫¤Ã¤¿¤Î¤Ç¤¹¡£ In the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, another prospective population-based cohort study with 7664 adults aged 20–75 years from The Netherlands found that low urinary magnesium excretion levels (a marker for low dietary magnesium intake) are associated with a higher risk of ischemic heart disease over a median follow-up period of 10.5 years . ¿Õ¡¤ª¤è¤Ó·ì´É¤ÎËö´ü¼À´µ¤ÎͽËÉ¡ÊPREVEND¡Ë¸¦µæ¤Ç¤Ï¡¢¥ª¥é¥ó¥À¤Î20〜75ºÐ¤Î7664¿Í¤ÎÀ®¿Í¤òÂоݤȤ·¤¿Ê̤ÎÁ°¸þ¤¤ÊÃϰ轸Ãĸ¦µæ¤¬¸«¤Ä¤«¤ê¤Þ¤·¤¿¡£
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National Center for Biotechnology Information, U.S. National Library of Medicine
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¡ØÆÍÁ³»àÂкö¡§¥Þ¥°¥Í¥·¥¦¥à¡Ù¡¡2018/11/28(¿å)
¡ØÍ½Ëɤȼ£ÎŤΥޥ°¥Í¥·¥¦¥à¡Ù¡¡2018/12/5(¿å)
Magnesium in Prevention and Therapy
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¡ØÆ¦ÉåÍѥ˥¬¥ê¤Ë¤è¤ë桦ÅüǢɡ١¡2018/12/25
¡Ø·ò¹¯¿Í¤Îɵ¤¤Ï°å»Õ¤¬¥µ¥×¥ê¤ÇÁϤë¡Ù¡¡2015/12/23(¿å)
5 Warning Signs of Magnesium Deficiency
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