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Cardiovascular Disease
Hypertension
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A substantial body of epidemiological and experimental research is linking magnesium deficiency and cardiovascular diseases such as hypertension and atherosclerosis . Hypertension is a major risk factor for heart disease and stroke. Magnesium is involved in blood pressure regulation. Every modification of the endogenous magnesium status leads to changes in vascular tonus and, as a consequence, changes in arterial blood pressure . 

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Magnesium deficiency increases angiotensin II-mediated aldosterone synthesis and the production of thromboxane and vasoconstrictor prostaglandins (see Figure 3) .Furthermore, alterations in the metabolism of calcium and magnesium have been implicated in the pathogenesis of primary hypertension. 

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Calcium influx across the external cellular membrane in smooth muscle cells and cardiomyocytes plays a crucial role in the control of cellular excitation contraction and impulse propagation. Intracellular calcium and magnesium concentrations are controlled by reversible binding to specific calcium-binding proteins. ¡ÊÃæÎ¬¡Ë

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The calcium and magnesium flux across the external membrane is regulated by a calcium pump (calcium-magnesium-ATPase), calcium channels, and binding to the membrane.  In cell membranes and in lymphocytes of hypertensive patients, our group showed significant increase of calcium, decrease of magnesium and an increased calcium/magnesium ratio (Ca2+/Mg2+ >2) . In addition, it could be shown experimentally that a lack of magnesium increases the risk for lipid peroxidation and the development of dyslipoproteinemia.

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In a meta-analysis of randomized trials, the effect of magnesium supplementation on blood pressure was tested. 

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 In borderline hypertension, decreased intracellular magnesium concentrations have recently been described. In patients with mild uncomplicated hypertension, respectively borderline hypertension, magnesium therapy can normalize blood pressure values . Magnesium supplementation may also have a positive effect on resting and recovery systolic blood pressure with aerobic and resistance exercise . 

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Magnesium supplementation can help to control blood pressure and reduce the cardiovascular risk factors (e.g., atherosclerosis) associated with hypertension, especially in hypertensive individuals who are depleted of magnesium due to chronic diuretic use, inadequate intake, or both .

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Coronary Heart Disease, Myocardial Infarction and Stroke
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Magnesium is a natural calcium antagonist and modulates vasomotor tone, blood pressure, and peripheral blood flow. Its actions as an antihypertensive, antidysrhythmic, anti-inflammatory and anticoagulant agent can be of benefit in the prevention and treatment of cardiovascular diseases. 

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Recent experimental studies with Wistar rats reveal that short magnesium deficiency is associated with a downregulation of telomerase in left ventricular, right ventricular, atrial and aortic muscle cells. 

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Furthermore a deficiency of magnesium resulted in these animal models in a 7–10 fold increased formation of 8-OH-dG in the cardiac and aortic muscle cells, and furthermore the magnesium deficiency is linked to an increased upregulation on neutral-sphingomyelinase (N-SMAse) and p53 in the cardiac and aortic muscle tissues . 

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Epidemiological studies have reported that serum and dietary magnesium are associated inversely with risk factors for coronary heart disease such as hypertension, type 2 diabetes mellitus, and the metabolic syndrome. Additional evidence from ecologic, clinical, and autopsy studies has shown higher magnesium to be potentially protective against sudden cardiac death. 

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Baking Soda May Help Fight Colds and the Flu
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Some people believe that when taken internally, baking soda can help maintain the pH balance in your bloodstream.This is likely the basic premise behind its recommended uses against both colds and influenza symptoms.In their booklet " Arm & Hammer Baking Soda Medical Uses ," published in 1924, Dr. Volney S. Cheney recounts his clinical successes with sodium bicarbonate in treating cold and flu: 2

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"In 1918 and 1919 while fighting the 'flu' with the U. S. Public Health Service it was brought to my attention that rarely anyone who had been thoroughly alkalinized with bicarbonate of soda contracted the disease, and those who did contract it, if alkalinized early, would invariably have mild attacks.

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I have since that time treated all cases of 'cold,' influenza and LaGripe by first giving generous doses of bicarbonate of soda, and in many, many instances within 36 hours the symptoms would have entirely abated.

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Further, within my own household, before Woman's Clubs and Parent-Teachers' Associations, I have advocated the use of bicarbonate of soda as a preventive for 'colds,' with the result that now many reports are coming in stating that those who took 'soda' were not affected, while nearly everyone around them had the 'flu.'

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Not too certain though about how valid the pH optimizing is as to baking soda's mechanism of action, as clinically I have frequently used diluted hydrochloric acid intravenously to also help people nearly instantly recover from acute infections. Obviously this is pushing the pH in the opposite direction, yet both appear to work, suggesting that the mode of action may be other than pH mediated.

The administration is easy enough, and is relatively harmless even if you should not experience relief from your cold symptoms. Simply dissolve the recommended amount of baking soda in a glass of cold water and drink it. Recommended dosages from the Arm & Hammer Company for colds and influenza back in 1925 were:

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Day 1 -- Take six doses of ½ teaspoon of baking soda in glass of cool water, at about two-hour intervals
Day 2 -- Take four doses of ½ teaspoon of baking soda in glass of cool water, at the same intervals
Day 3 -- Take two doses of ½ teaspoon of baking soda in glass of cool water morning and evening, and thereafter ½ teaspoon in glass of cool water each morning until cold symptoms are gone

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According to Arm & Hammer's dosing instructions, do not exceed seven doses of ½ teaspoon per day, or three doses of ½ teaspoon daily if you're over the age of 60. In addition, do not use the maximum dosage for more than two weeks.

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Natural Ways To Prevent and Treat Influenza
To keep your immune system strong eat a healthy diet, get regular exercise, proper rest with some relaxation time every day and adequate sleep (most people need about 8 hours).
Organic, local, fresh food is optimal and try to avoid processed food such as white flour, sugar, and artificial sweeteners/high fructose corn syrup.

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Glass of wine a day raises breast cancer risk
by JENNY HOPE, Daily Mail
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Cancer warning for women who like a glass of wine or three
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Study shows that those who enjoy wine with dinner are putting their lives at risk

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Thursday 29 March 2012  
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One glass
Increases risk of breast cancer by 4 to 5 per cent

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Two glasses¡¡Increase the risk by 25 to 35 per cent¡¡

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Three glasses¡¡Increase the risk by 40 to 50 per cent.

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French government new advice: 'Don't drink wine'
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2009ǯ2·î20Æü
The French wine industry is – once again – up in arms at the government's latest pronouncement: to stop drinking wine altogether.

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The Ministry of Health has published guidelines which advise, 'The consumption of alcohol, and especially wine, is discouraged.'
The advice is drawn from findings by the INCA, the French national cancer institute, which says the consumption of only a small amount of alcohol can increase the risk of mouth and throat cancer by 168%.

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The wine lobby in France has reacted with outrage. 'This persecution of wine has to stop, the AGPV (the General Association of Wine Producers) said.
Xavier de Volontat, president of the southern Languedoc wine producers association told Times online, 'The extremists must not be allowed to take consumers hostage. Wine consumption has dropped bgy 50% over the last 20 years in France, but cancer has increased. You have to admit there is a paradox.

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'We are for responsible, reasonable and moderate consumption. It is not in our interests to see our consumers dying of cancer¡Ä'

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Drinking just one glass of wine a day can INCREASE risk of cancer by 168%, say the French! 

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23 February 2009

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'There is very little evidence that red wine has any specific benefits over other alcoholic drinks.'

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'The cause is above all the transformation of ethanol in alcohol to acetaldehyde, which damages DNA in healthy cells.'

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Dr Jodie Moffat, of charity Cancer Research UK, said: 'We know that drinking just small amounts of alcohol, in the form of beer, wine or spirits, increases the risk of several different types of cancer.

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'So the more you cut down on alcohol, the more you can reduce your cancer risk.'

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A separate study last year published in the medical journal Neurology said those who drank modest amounts of alcohol developed dementia, including Alzheimer's disease, at an 85 per cent slower rate than those who did not drink.

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A systematic review and meta-analysis of prospective studies that comprised 313,041 individuals and 11,995 cardiovascular diseases, 7534 ischemic heart diseases, and 2686 fatal ischemic heart disease events found that higher serum levels of magnesium were significantly associated with a lower risk of cardiovascular disease, and higher dietary magnesium intakes (up to approximately 250 mg/day) were associated with a significantly lower risk of ischemic heart disease caused by a reduced blood supply to the heart muscle. 

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Circulating serum magnesium (per 0.2 mmol/L increment) was associated with a 30% lower risk of cardiovascular disease (RR: 0.70; 95% CI: 0.56, 0.88 per 0.2 mmol/L) and trends toward lower risks of IHD (RR: 0.83; 95% CI: 0.75, 1.05) and fatal ischemic heart disease (RR: 0.61; 95% CI: 0.37, 1.00). Dietary magnesium (per 200 mg/day increment) was not significantly associated with cardiovascular disease (RR: 0.89; 95% CI: 0.75, 1.05) but was associated with a 22% lower risk of ischemic heart disease (RR: 0.78; 95% CI: 0.67, 0.92). The association of dietary magnesium with fatal ischemic heart disease was nonlinear (p < 0.001), with an inverse association observed up to a threshold of ~250 mg/day (RR: 0.73; 95% CI: 0.62, 0.86), compared with lower intakes .

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In a monocentric, controlled, double-blind study, 79 patients with severe congestive heart failure (NYHA IV) under optimal medical cardiovascular treatment were randomised to receive either magnesium orotate (6000 mg for 1 month, 3000 mg for about 11 months, n = 40) or placebo (n = 39). Both groups were comparable in demographic data, duration of heart failure and pre- and concomitant treatment. After mean treatment duration of 1 year (magnesium orotate: 364.1 +/¡Ý 14.7 days, placebo: 361.2 +/¡Ý 12.7 days) the survival rate was 75.7% compared to 51.6% under placebo (p < 0.05). Clinical symptoms improved in 38.5% of patients under magnesium orotate, whereas they deteriorated in 56.3% of patients under placebo (p < 0.001) .

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Magnesium orotate may be used as adjuvant therapy in patients on optimal treatment for severe congestive heart failure, increasing survival rate and improving clinical symptoms and patient¡Çs quality of life.

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A meta-analysis of seven prospective trials with a total of 241,378 participants observed a modest but statistically significant inverse association between magnesium intake and risk of stroke. An intake increment of 100 mg Magnesium/day was associated with an 8% reduction in risk of total stroke (combined RR: 0.92; 95% CI: 0.88, 0.97). Magnesium intake was inversely associated with risk of ischemic stroke (RR: 0.91; 95% CI: 0.87, 0.96) but not intracerebral hemorrhage (RR: 0.96; 95% CI: 0.84, 1.10) or subarachnoid hemorrhage (RR: 1.01; 95% CI: 0.90, 1.14) . In an updated meta-analyses of prospective studies to date, the combined RR of total stroke was 0.87 (95% CI: 0.83, 0.92) for a 100 mg/day increase in magnesium intake, 0.91 (95% CI: 0.88, 0.94) for a 1000 mg/day increase in potassium intake, and 0.98 (95% CI: 0.94, 1.02) for a 300 mg/day increase in calcium intake .

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Magnesium sulfate is neuroprotective in preclinical models of stroke and has shown signals of potential efficacy with an acceptable safety profile when delivered early after stroke onset in humans. In a recent study, 1700 patients with suspected stroke received either intravenous magnesium sulfate or placebo, beginning within 2 h after symptom onset. Prehospital initiation of magnesium sulfate therapy was safe and allowed the start of therapy within 2 h after the onset of stroke symptoms, but it did not improve disability outcomes at 90 days .

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In hemodialysis patients, low magnesium status is associated with other risk factors for cardiovascular disease such as greater incidence of intradialytic hypotension, poorer hemodialysis adequacy, deteriorating calcium-phosphate metabolism, inflammation and carotid intima-media thickness .

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Cardiac arrhythmias are well known to be associated with hypomagnesaemia, although the contribution of hypomagnesaemia to its pathogenesis is not fully known due to coexisting hypokalaemia and other electrolyte disturbances. Possible effects of magnesium in preventing cardiac arrhythmias are stabilization of electrolyte concentrations of the heart muscle cell and membranes, calcium antagonism,,elevation of cell energy niveau, improvement in O2 utilisation and diminishing of neurotransmitter release, e.g..adrenaline or noradrenaline. Magnesium depletion increases susceptibility to arrhythmogenic effects of drugs such as cardiac glycosides. The spectrum includes supraventricular and ventricular arrhythmias. Magnesium has a well-established role in the management of torsade de pointes. Torsade de pointes, a repetitive polymorphous ventricular tachycardia with prolongation of QT intervals, has been reported in cases of hypomagnesaemia, and this and other arrhythmias have been successfully treated with intravenous magnesium. In the recent guideline of the American Heart Association and the American College of Cardiology for prevention and treatment of torsade de pointes, tachycardia administration of magnesium and potassium is advised .

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The frequency of cardiac arrhythmias occurring after myocardial infarction is higher in hypomagnesemic patients and can be reduced by magnesium administration. Several trials indicate that an intravenous magnesium infusion early after suspected myocardial infarction could decrease the risk of death. A meta-analysis with 2316 patients of the Leicester Intravenous Magnesium Intervention Trial (LIMIT-2) found a significant reduction in mortality in those patients who were given intravenous magnesium sulfate (8 mmol over 5 min followed by 65 mmol over 24 h) within 24 h of suspected myocardial infarction or physiological saline. By intention-to-treat analysis mortality from all causes was 7.8% in the magnesium group and 10.3% in the placebo group (2 p = 0.04), a relative reduction of 24% (95% confidence interval 1%–43%) . However, another study involving 58,050 patients with suspected myocardial infarction, (ISIS-4, Fourth International Study of Infarct Survival), showed no benefit from magnesium therapy . Also in the Magnesium in Coronaries (MAGIC) trial with 6213 patients with acute ST-elevation myocardial infarction, magnesium therapy had no benefit . Thus, the use of intravenous magnesium sulphate remains controversial. Nevertheless, magnesium therapy should be considered in those with refractory arrhythmias.

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A substantial body of epidemiological and experimental research is linking magnesium deficiency and cardiovascular diseases such as hypertension and atherosclerosis .Hypertension is a major risk factor for heart disease and stroke. Magnesium is involved in blood pressure regulation. Every modification of the endogenous magnesium status leads to changes in vascular tonus and, as a consequence, changes in arterial blood pressure 

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Furthermore, alterations in the metabolism of calcium and magnesium have been implicated in the pathogenesis of primary hypertension. Calcium influx across the external cellular membrane in smooth muscle cells and cardiomyocytes plays a crucial role in the control of cellular excitation contraction and impulse propagation. Intracellular calcium and magnesium concentrations are controlled by reversible binding to specific calcium-binding proteins. 

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The calcium and magnesium flux across the external membrane is regulated by a calcium pump (calcium-magnesium-ATPase), calcium channels, and binding to the membrane. In cell membranes and in lymphocytes of hypertensive patients, our group showed significant increase of calcium, decrease of magnesium and an increased calcium/magnesium ratio (Ca2+/Mg2+ >2) . 

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In addition, it could be shown experimentally that a lack of magnesium increases the risk for lipid peroxidation and the development of dyslipoproteinemia.

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Magnesium is a natural calcium antagonist and modulates vasomotor tone, blood pressure, and peripheral blood flow. Its actions as an antihypertensive, antidysrhythmic, anti-inflammatory and anticoagulant agent can be of benefit in the prevention and treatment of cardiovascular diseases. Recent experimental studies with Wistar rats reveal that short magnesium deficiency is associated with a downregulation of telomerase in left ventricular, right ventricular, atrial and aortic muscle cells.Furthermore a deficiency of magnesium resulted in these animal models in a 7–10 fold increased formation of 8-OH-dG in the cardiac and aortic muscle cells, and furthermore the magnesium deficiency is linked to an increased upregulation on neutral-sphingomyelinase 

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Epidemiological studies have reported that serum and dietary magnesium are associated inversely with risk factors for coronary heart disease such as hypertension, type 2 diabetes mellitus, and the metabolic syndrome. Additional evidence from ecologic, clinical, and autopsy studies has shown higher magnesium to be potentially protective against sudden cardiac death. 

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The Atherosclerosis Risk in Communities (ARIC) Study assessed risk factors and levels of serum magnesium in a cohort of 7887 women and 6345 men aged 45–64 years. After an average of 12 years of follow-up, individuals in the highest quartile of the normal physiologic range of serum magnesium (≥0.88 mmol/L) had an almost 40% reduced risk of sudden cardiac death compared with individuals in the lowest quartile (≤0.75 mmol/L) (HR: 0.62, 95% CI: 0.42–0.93) . 

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Another prospective study examined 88,375 women to determine whether serum magnesium levels measured early in the study and magnesium intakes from food and supplements assessed every 2–4 years were associated with sudden cardiac death over 26 years of follow-up. Women in the highest compared with the lowest quartile of daily ingested magnesium (<261 mg/day vs. >345 mg/day) and plasma magnesium concentrations (<0.78 mmol/L vs. >0.86 mmol/L) had a 37% (relative risk: 0.63; 95% CI: 0.44, 0.91) and 77% (relative risk: 0.23; 95% CI: 0.09, 0.60) lower risk of sudden cardiac death, respectively .

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In the Prevention of Renal and Vascular End-Stage Disease (PREVEND) study, another prospective population-based cohort study with 7664 adults aged 20–75 years from The Netherlands found that low urinary magnesium excretion levels (a marker for low dietary magnesium intake) are associated with a higher risk of ischemic heart disease over a median follow-up period of 10.5 years . 

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