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Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats
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The antioxidant, immunomodulatory, and anti-inflammatory activities of Spirulina: an overview.
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Dietary supplementation with blueberries, spinach, or spirulina reduces ischemic brain damage.
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Potential applications of radioprotective phytochemicals from marine algae
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The Health Benefits of Spirulina—Blue-Green Algae
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Spirulina: An Emerging Treatment Modality for the. Management of Oral Submucous Fibrosis. 
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Food Kills Cancer
I¡Çve witnessed first hand the killing of cancer with food. I¡Çve heard of so many stories of people killing their own cancer with food. I¡Çd love to see the information get out there so people can start trusting someone other than their doctor prescribing only radical surgery, chemotherapy and radiation. There is no one answer — eat these foods and be healthy forever. But rather I¡Çve found that part of the process of healing one¡Çs cancer is to go on a quest. The mere act of engaging in the quest is HEALING. For us it also feels exciting, gives meaning and helps others. So let¡Çs go.

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Spirulina¡¡Radiation removal
The ethanol precipitate of the hot water extract from Spirulina platensis has shown protective effects on ¦Ã-ray irradiated mouse bone marrow cells ( Qishen et al. 1989 ).
& Kolman, A. 1989. Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test.

Spirulina : An Emerging Treatment Modality for the
Management of Oral Submucous Fibrosis

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Role in Periodontitis
Periodontitis is primarily an inflammatory condition
caused by bacteria in plaque.
set up against the gram negative bacterial organisms.
Mahendra et al 23 were the first to use Spirulina in the
treatment of periodontitis.
They assessed the role of Spi-
rulina in situ gel in periodontitis cases that were primarily
treated by scaling and root planning (SRP).
treated with both SRP and Spirulina gel after 120 days
depicted a reduction in mean probing pocket depth and
improvement in clinical attachment levels as compared to
the group treated with SRP alone.
They put forth that Spi-
rulina by its anti-inflammatory activity greatly improved
the gingival condition in patients with periodontitis and
that it can serve as a promising treatment modality.

The Health Benefits of Spirulina—Blue-Green Algae
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Chemo- and radio-protective effects of polysaccharide of Spirulina platensis on hemopoietic system of mice and dogs.
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Potential applications of radioprotective phytochemicals from marine algae
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Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats
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Mohamed M Abdel-Daim , Said Mahmoud Moustafa Abuzead , Safaa M. Halawa¡¦ Published¡¡n PloS one 2013
DOI: 10.1371/journal.pone.0072991
Deltamethrin is a broad-spectrum synthetic pyrethroid insecticide and acaricide widely used for agricultural and veterinary purposes.However, its human and animal exposure leads to hepatonephrotoxicity.Therefore, the present study was undertaken to examine the hepatonephroprotective and antioxidant potential of Spirulina platensis against deltamethrin toxicity in male Wistar albino rats.Deltamethrin treated animals revealed a significant increase in serum biochemical parameters as well as¡Ä CONTINUE READING

Mohamed M Abdel-Daim¡¢Sah Mahmoud Moustafa Abuzead¡¢Safaa M. Halawa¡¦½ÐÈǤµ¤ì¤Æ¤¤¤Þ¤¹n PloS one 2013
DOI¡§10.1371 / journal.pone.0072991
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Mohamed M Abdel-Daim , Said Mahmoud Moustafa Abuzead , Safaa M. Halawa¡¦ Published¡¡n PloS one 2013
DOI: 10.1371/journal.pone.0072991
Deltamethrin is a broad-spectrum synthetic pyrethroid insecticide and acaricide widely used for agricultural and veterinary purposes.However, its human and animal exposure leads to hepatonephrotoxicity.Therefore, the present study was undertaken to examine the hepatonephroprotective and antioxidant potential of Spirulina platensis against deltamethrin toxicity in male Wistar albino rats.Deltamethrin treated animals revealed a significant increase in serum biochemical parameters as well as¡Ä CONTINUE READING

Dietary supplementation with blueberries, spinach, or spirulinareduces ischemic brain damage
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Protective Role of Spirulina platensis against Acute Deltamethrin-Induced Toxicity in Rats
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Mohamed M Abdel-Daim , Said Mahmoud Moustafa Abuzead , Safaa M. Halawa¡¦ Published¡¡n PloS one 2013¡¡DOI: 10.1371/journal.pone.0072991

Abstract¡¡Í×Ìó
Deltamethrin is a broad-spectrum synthetic pyrethroid insecticide and acaricide widely used for agricultural and veterinary purposes.
However, its human and animal exposure leads to hepatonephrotoxicity. 
Therefore, the present study was undertaken to examine the hepatonephroprotective and antioxidant potential of Spirulina platensis against deltamethrin toxicity in male Wistar albino rats. 
Deltamethrin treated animals revealed a significant increase in serum biochemical parameters as well as hepatic and renal lipid peroxidation but caused an inhibition in antioxidant biomarkers. 
Spirulina normalized the elevated serum levels of AST, ALT, APL, uric acid, urea and creatinine.
 Furthermore, it reduced deltamethrin-induced lipid peroxidation and oxidative stress in a dose dependent manner. 
Therefore, it could be concluded that spirulina administration able to minimize the toxic effects of deltamethrin by its free radical-scavenging and potent antioxidant activity.

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Oral health in China: from vision to action
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More importantly, oral infectious diseases, particularly periodontitis, are also closely associated with systemic diseases such as diabetes, cardiovascular diseases, rheumatoid arthritis, preterm birth, respiratory diseases, colorectal cancer, inflammatory bowel diseases and Alzheimer's disease  .

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Traditional Chinese medicine (TCM), which has been developed for more than 2 000 years, has attracted increasing attention recently, particular due to its comparable efficacy and reduced side-effects for the treatment of NCDs
Although standard criteria for post-treatment assessment are not available and the exact of TCM mechanisms are still unclear, TCM has shown effectiveness in the treatment of oral diseases, including dental caries, periodontitis, recurrent aphthous stomatitis, oral lichen planus, leukoplakia, and Sjogren's syndrome, etc.

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Oral health in China: from vision to action
The challenge of oral diseases
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Most oral diseases are NCDs.
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The most common oral diseases include untreated caries in permanent teeth, untreated caries in deciduous teeth, and severe periodontitis in adults.

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Spirulina : An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis
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Role in Periodontitis Periodontitis is primarily an inflammatory condition caused by bacteria in plaque.set up against the gram negative bacterial organisms.
Mahendra et al 23 were the first to use Spirulina in the treatment of periodontitis.

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They assessed the role of Spi-rulina 
in situ gel in periodontitis cases that were primarily treated by scaling and root planning (SRP).treated with both SRP and Spirulina gel after 120 days depicted a reduction in mean probing pocket depth and improvement in clinical attachment levels as compared to
the group treated with SRP alone.

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They put forth that Spi-rulina by its anti-inflammatory activity greatly improved the gingival condition in patients with periodontitis and that it can serve as a promising treatment modality.

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Spirulina: An Emerging Treatment Modality for the Management of Oral Submucous Fibrosis
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an anticancer agent.
9,23 Research has highlighted its role
in the control of various diseases caused due to oxidative stress.
23 Additionally, Spirulina due to its high iron content (580–1800 mg/kg) and lack of oxalates or phytates in algal structure, does not interfere with iron absorption.
31,32 This has led to its use in the treatment of anemia.

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Role in Periodontitis 
Periodontitis is primarily an inflammatory condition set up against the gram negative bacterial organisms.
Mahendra et al 23 were the first to use Spirulina in the treatment of periodontitis.
They assessed the role of Spi-rulina in situ gel in periodontitis cases that were primarily treated by scaling and root planning (SRP).treated with both SRP and Spirulina gel after 120 days depicted a reduction in mean probing pocket depth and improvement in clinical attachment levels as compared to the group treated with SRP alone.They put forth that Spi-rulina by its anti-inflammatory activity greatly improved the gingival condition in patients with periodontitis and that it can serve as a promising treatment modality.

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Spirulina Platensis
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Alga Spirulina has one of the highest concentration of nutrients than any other food known to mankind till date. 

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➀Spirulina is upto 4000% or more natual betacarotene than the orange carrots.
②Spirulina has 2000% or more iron than leafy spinach.
➂Spirulina has 260% or more calcium than milk.
④Spirulina has upto 400% or more protein than meat and 200% or more than Soybeans. It's a bio-nutrient packed vegetarian entity.
⑤Few grams of Spirulina have more antioxidant and antiinflammatory activity than many servings of many assorted vegetable and fruits.
⑥Comparing bioavailable phytonutrient levels, Spirulina is 30 times or more potent than blueberries, 50 times more potent than spinach and 600 times or more potent than many fruits especially apples.

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Spectrum of nutrients found in Spirulina are; over a dozens of different vitamins, minerals, natural mixed carotenoids (NMCs), 18 amino acids, many enzymes, all of the essential fatty acids PUFA and many a health heal ingredients. Spirulina can help to prevent and reverse severe anemia. This algae is very good ally to boost your immune system and it’s also a very fitting anti-aging, antioxidant and anti-inflammatory bio-resource. Spirulina ably help to reduce the bad cholesterol level effectively and naturally and increases the good and much needed gut bacterial profile immensely. Spirulina can be a nutritional food for brain will help to protect against Alzheimer, Parkinson and other neurodegenerative diseases. Spirulina is also good nutrient source for pregnant and nursing mothers. It ensures proper lactation and baby growth naturally. Spirulina can help human body to DETOX by removing unwanted heavy metals with almost no side effects. It's a vegetarian source of vitamin B-12. And a great veg source of the Folic acid. 

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Arthrospira platensis

Description and significance
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Regulatory Efficacy of Spirulina platensis Protease Hydrolyzate on Lipid Metabolism and Gut Microbiota in High-Fat Diet-Fed Rats

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Collectively, the above-mentioned findings illustrate that Spirulina platensis peptides have the potential to ameliorate lipid metabolic disorders, and our data provides evidence that SPPH might be used as an adjuvant therapy and functional food in obese and diabetic individuals. 

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The Potential Application of Spirulina ( Arthrospira ) as a Nutritional and Therapeutic Supplement in Health Management

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Protective effect of Spirulina against cyclophosphamide-induced urotoxicity in mice
Volume 5, Issue 3, September 2018, Pages 191-196

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Abstract
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Cyclophosphamide (CP) is an anti-neoplastic drug, which is widely used for treating cancer and non-malignant tumors. 

One of the major side effects of CP is hemorrhagic cystitis. Spirulina (Arthrospira platensis; Sp) is a blue-green algae with the ability to attenuate oxidative stress, which may be utilized for alleviating side effects of chemotherapeutic drugs in the clinic. 

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CP¤Î¼ç¤ÊÉûºîÍѤÎ1¤Ä¤Ï½Ð·ìÀ­ç¯æù±ê¤Ç¤¹¡£¥¹¥Ô¥ë¥ê¥Ê¡ÊArthrospira platensis; Sp¡Ë¤Ï¡¢»À²½¥¹¥È¥ì¥¹¤ò·Ú¸º¤¹¤ëǽÎϤò»ý¤ÄÍõÁôÎà¤Ç¡¢¿ÇÎŽê¤Ç²½³ØÎÅË¡Ìô¤ÎÉûºîÍѤò·Ú¸º¤¹¤ë¤¿¤á¤ËÍøÍѤ¹¤ë¤³¤È¤¬¤Ç¤­¤Þ¤¹¡£

The aim of the present study was to evaluate the ability of Sp, to protect mice from cyclophosphamide-induced urotoxicity and hemorrhagic cystitis due to its antioxidant properties. 
Adult female mice were orally administered Sp (600 g/kg body weight/day) over nine days as well as a single dose of CP (40 mg/kg body weight) intraperitoneally either four days previously (CP + Sp group) or four days after the start of Sp intake (Sp + CP group); two further groups were treated with either Sp or CP only, respectively. 

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À®ÂλóÀ­¥Þ¥¦¥¹¤Ë¡¢9Æü´Ö¤Ë¤ï¤¿¤Ã¤ÆSp¡Ê600g / kgÂνÅ/Æü¡Ë¡¢¤Ê¤é¤Ó¤Ë4Æü´ÖÁ°¡ÊCP + Sp·²¡Ë¤Þ¤¿¤Ï4Æü´Ö¤Î¤¤¤º¤ì¤«¤Çñ²óÅêÍ¿Î̤ÎCP¡Ê40mg / kgÂνšˤòÊ¢¹ÐÆâÅêÍ¿¤·¤¿¡£ £Ó£ðÀݼ賫»Ï¸å¡Ê£Ó£ð ¡Ü £Ã£Ð·²¡Ë¡£¤µ¤é¤Ë2¤Ä¤Î¥°¥ë¡¼¥×¤Ï¡¢¤½¤ì¤¾¤ìSp¤Þ¤¿¤ÏCP¤Î¤ß¤Ç¼£ÎŤ·¤¿¡£

The results showed that CP induced hemorrhagic cystitis in mice, with levels of malondialdehyde (MAD) significantly increased and those of glutathione (GSH) decreased compared with the control group (P < 0.05), while the opposite effects were observed in the mice who received Sp only (P < 0.05). 

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Furthermore, in the CP + Sp group, MAD and GSH levels were improved compared with those in the CP only group, and in the Sp + CP group, the effects of CP were reversed. 
In addition, histomorphological alterations of the urinary bladder were significantly lower than those in the CP group.

¤µ¤é¤Ë¡¢CP + Sp·²¤Ç¤Ï¡¢MAD¡ÊÃ𣱡ˤª¤è¤Ó¥°¥ë¥¿¥Á¥ª¥ó¡ÊGSH¡Ë¡ÊÃ𣲡˥ì¥Ù¥ë¤ÏCPñÆÈ·²¤Î¤½¤ì¤é¤ÈÈæ³Ó¤·¤Æ²þÁ±¤µ¤ì¡¢Sp + CP·²¤Ç¤Ï¡¢CP¤Î¸ú²Ì¤ÏµÕž¤·¤¿¡£

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 In conclusion, pre-treatment with Sp protected mice from CP-induced urotoxicity, probably via its anti-oxidant and anti-apoptotic properties.

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Cadmium-induced hematological, renal, and hepatic toxicity: The amelioration by spirulina platensis
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Date of Web Publication¡¡25-May-2018
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Background: spirulina platensis (SP) is known as a valuable additional food and therapeutic agent. 

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Objective: We investigate the protective effect of SP on cadmium (Cd)-induced hematological, renal and hepatic toxicity in rats. 

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Histopathological examination

Cd-induced hepatic and renal damage was demonstrated through histopathological investigations. This severe hepatic damage after Cd exposure included the existence of outspread hepatocytes degeneration, necrosis, inflammation, cytoplasmic vacuolization, and various cellular debris within the central liver vein [Figure 2]c when compared with control and SP-treated rats [Figure 2]a and [Figure 2]b, respectively]. However, the combination groups of Cd-spirulina showed prominent recovery in the form of the liver histoarchitecture such as the reduced cytoplasmic vacuolization, the normal sinusoidal spaces, and the lamellar pattern of hepatocytes was restored to almost normal [Figure 2]d.

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Figure 2: Effect of spirulina coadministered with cadmium on histological damage in the liver. (a) Control and (b) Spirulina platensis group showed normal histoarchitecture of the liver (c) cadmium group showed extensive degeneration of hepatocytes with necrosis, inflammation, the presence of cellular debris within a central vein, and cytological vacuolization (d) cadmium + Spirulina platensis group showed prominent recovery in the form of reduced cytoplasmic vacuolization, the normal sinusoidal spaces, and the lamellar pattern of hepatocytes was restored to almost normal (H and E, 400Ũ)

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Transverse sections of the kidney in control and SP alone-treated rats showed normal glomeruli and renal tubules [Figure 3]a and [Figure 3]b, respectively]. Whereas, Cd intoxicated rats showed cellular glomeruli, congestion cortex, and outer medulla such as tubular brush border loss, interstitial edema, and necrosis of epithelium [Figure 3]c. On the other hand, concomitant treatment with SP exhibited minimal histological changes in kidney limited only to tubular cells [Figure 3]d.

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Figure 3: Effect of spirulina coadministered with cadmium on histological damage in the kidney. (a) Control and (b) Spirulina platensis-treated groups showed normal glomeruli and renal tubules (c) cadmium-treated group showed cellular glomeruli, congestion cortex and outer medulla such as tubular brush border loss, interstitial edema, and necrosis of epithelium (d) cadmium + Spirulina platensis-treated group exhibited minimal histological changes in kidney limited only to tubular cells (H and E, 400Ũ)
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