不随意な日々〜子どもへの少量l-dopa療法についての情報

☆発達障害(自閉症など)でドパストン散(l-dopa)を処方された人を探しています☆

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専門誌に掲載された論文です。
自閉症児に対してL-DOPA(レボドパ)を投与した、もっとも古い研究報告だと思われます。
 
1971, Volume 1, Issue 2, pp 190-205

Effects of L-dopa in autism

Dr. Edward R. Ritvo, Arthur Yuwiler, Edward Geller, Anthony Kales, Shirley Rashkis, Aric Schicor, Selma Plotkin, Robert Axelrod, Carla Howard
 

Abstract

A study was designed to determine if blood serotonin concentrations could be lowered in autistic children by the administration of L-dopa and, if so, to observe possible clinical or physiological changes. Following a 17-day placebo period, four hospitalized autistic boys (3, 4, 9, and 13 years of age) received L-dopa for 6 months. Results indicated a significant decrease of blood serotonin concentrations in the three youngest patients, a significant increase in platelet counts in the youngest patient, and a similar trend in others. Urinary excretion of 5HIAA decreased significantly in the 4-year-old patient and a similar trend was noted in others. No changes were observed in the clinical course of the disorder, the amount of motility disturbances (hand-flapping), percent of REM sleep time, or in measures of endocrine function (FSH and LH). Possible mechanisms by which L-dopa lowered blood serotonin concentrations, increased platelet counts, and yet failed to produce other changes are discussed.
springer link のプレビューページより一部転載
イメージ 1
 
 
 
 
 
抄録を読む限り、L-dopaの投与でセロトニン血中濃度が下がったとあります。
で、だからどうなの? 
ということは中身を読まないとわかりません。
 
Referenceを含めて16ページの論文で、うんざりですが。。。 
 
 
 
効果がなかったようです。
 
 
 


 
 
Refer to: Ornitz EM: Childhood aLtism-A revicw of the clinical
            and experimental litcrattire (Medical Progress). Calif
            Med 118:21-47, Apr 1973
MEDICAL PROGRESS
 
Childhood Autism
 
A Review of the Clinical and Experimental Literature

EDWARD M. ORNITZ, MD, Los Angeles

This review of the literature on childhood autism discusses the
clinical characteristics, differential diagnosis, prognosis and
treatment of the autistic behavioral syndrome from a developmental
perspective. It includes a discussion of the influence of
prenatal and perinatal antecedents, genetic and socio-familial
factors, and epidemiologic considerations. Neurologic, electroencephalographic
and experimental neurophysiologic, metabolic,
biochemical and hematologic investigations are reviewed.
Special emphasis has been given to the changing clinical manifestations
which accompany maturation and to the problems of
recognition of childhood autism in the very young child.
 
 
CALIFORNIA MEDICINE  The Western Journal of Medicine
 
こちらは、自閉症に関する論文調査の報告で、自閉症全体について、薬物療法も含めて書いてあります。
こちらもかなりの量ですが、薬物療法の部分、特にL-dopaについてはほんの数行で、結論としては、効果なしとしています。
 
 
 
 
 
 
 
 
 

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